We are providing technical services on the formulation development of novel and smart materials assisted drug delivery systems for better performances to our business partners. In this area, we are specifically focusing on the synthesis of novel excipients (eg. polymers, lipids) and their applications for the formulation development of smart nanoparticulate delivery systems for antibiotics.
Bacterial infections are continued to be one of the major cause of morbidity and mortality worldwide. Antibiotics in conventional dosage forms have various limitations including inadequate drug concentration at infection/target sites, fast degradation and quick elimination in the bloodstream, high frequency of administration, severe side effects and poor patient compliance. The increasing use of antibiotics in the medical practice and limitations associated with their conventional dosage forms have resulted in the current global antimicrobial resistance crisis. Apart from the bacterial resistance to the currently available antibiotics, development of newer antibiotics is in the stagnant phase because of low return on investments for the pharmaceutical industries. Various strategic solutions are therefore warranted to improve the treatment of susceptible and resistant bacterial infections.
Nano drug delivery systems are showing significant potential for an effective treatment of susceptible and resistant bacteria and overcoming the various limitations associated with the conventional dosage forms of antibiotics. Therefore, considering the slow development rate of newer antibacterial drugs and the ongoing problem of superbugs, there is an urgent need to design and develop novel nano-based strategies using smart materials to improve antibacterial activity of non-drug antibacterial materials and currently available antibiotics against susceptible and resistant bacteria.